Sanggenone C

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sanggenone C 通过诱导细胞周期停滞和细胞死亡，抑制蛋白酶体功能，从而抑制肿瘤细胞蛋白酶体活性和细胞活力。

Sanggenone C inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. Sanggenone C and O inhibited NO production and iNOS expression by suppressing NF-κB activity and IκBα activation; inhibited TNF-alpha -stimulated PMN-HSC adhesion and expression of VCAM-1 by suppressing the activation of NF-kappaB.

Cell Proliferation Assay Cell Line:Human GC cell lines HGC-27 and AGS cells Concentration:4-12 μM Incubation Time:24 hResult:Inhibited the proliferation of GC cells in a dose-dependent manner. The IC50 values of were 9.129 μM for HGC-27 and 9.863 μM for AGS.Cell Cycle Analysis Cell Line:Human GC cell lines HGC-27 and AGS cells Concentration:6, 8, 10 μM Incubation Time:24 h Result:The proportions of cells in the G0-G1 phase were increased and the levels of CDK4 and cyclin D1 were decreased. Apoptosis Analysis Cell Line:Human GC cell lines HGC-27 and AGS cells Concentration:6, 8, 10 μM Incubation Time:24 h Result:Exhibited a dose-dependent induction of apoptosis, with the percentage of apoptotic cells increasing from 7.3% to 24.8% and from 4.6% to 15.1% for HGC-27 and AGS cells, respectively.Western Blot Analysis Cell Line:Human GC cell lines HGC-27 and AGS cells Concentration:6, 8, 10 μM Incubation Time:24 h Result:The levels of p-ERK were markedly downregulated.

Animal Model:Male C57/BL6 mice (weight 23.5-27.5 g; age, 8 weeks)Dosage:10, 20 mg/kg Administration:Intraperitoneally; daily; for 3 weeks Result:Prevented the development of ventricular dysfunction, as evidenced by decreased LV end-diastolic diameter, LV end-systolic diameter, and increased LVFS and LVEF.

Sanggenone C | Sanggenon C

GPCR/G Protein

Antibacterial

NF-κB

——

——

80651-76-9

708.71

C40H36O12

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (141.10 mM)

CC1=CC(C(C(C1)C2=C(C=C(C=C2)O)O)C(=O)C3=C(C=C(C=C3)O)O)C4=C(C=C5C(=C4O)C(=O)C6(C(O5)(C7=C(O6)C=C(C=C7)O)CC=C(C)C)O)O

2-((1S,2R,3S)-2-(2,4-dihydroxybenzoyl)-2',4'-dihydroxy-5-methyl-1,2,3,6-tetrahydro-[1,1'-biphenyl]-3-yl)-1,3,8,10a-tetrahydroxy-5a-(3-methylbut-2-en-1-yl)-5a,10a-dihydro-11H-benzofuro[3,2-b]chromen-11-one

(-20℃)

With Ice Pack

≥ 2 years